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adhd [2025/12/22 22:13] – [introduction] gary1adhd [2025/12/22 22:14] (current) – [introduction] gary1
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   *AD/HD consists of a pattern of behavior that is present in multiple settings where it gives rise to social, educational or work performance difficulties   *AD/HD consists of a pattern of behavior that is present in multiple settings where it gives rise to social, educational or work performance difficulties
   *it is a developmental disorder and it would appear over 99% have symptom onset prior to 7yrs of age, and most fit the criteria before age 3 yrs, although recall of such symptoms in adult life can be poor with only 50% recalling symptoms prior to age 7yrs while 95% can recall symptoms prior to age 12 years   *it is a developmental disorder and it would appear over 99% have symptom onset prior to 7yrs of age, and most fit the criteria before age 3 yrs, although recall of such symptoms in adult life can be poor with only 50% recalling symptoms prior to age 7yrs while 95% can recall symptoms prior to age 12 years
-  *it is now regarded as a persistent neurodevelopmental disorder impairing executive functioning (EF), or the "management system" of the brain, that usually persists into adulthood and can be an important co-morbid factor in adult pyschiatric illnesses and substance abuse+  *it is now regarded as a persistent neurodevelopmental disorder impairing executive functioning (EF), or the "management system" of the brain, that usually persists into adulthood and can be an important co-morbid factor in adult psychiatric illnesses and substance abuse
   *it is estimated to affect 3-5% of children.   *it is estimated to affect 3-5% of children.
-  *the gene Homer1 may have an important role in attention+  *the gene Homer1 may have an important role in genetic variances in attention
     * a mouse study in 2025 found that reducing expression of Homer1 in prefrontal cortex neurons where attention is based, caused those cells to upregulate GABA receptors-the molecular brakes of the nervous system. This shift created a quieter baseline and more focused bursts of activity when cues appeared: instead of firing indiscriminately, neurons conserved their activity for moments that mattered, enabling more accurate responses. (([[https://www.nature.com/articles/s41593-025-02155-2|2025: Genetic mapping identifies Homer1 as a developmental modifier of attention]]))     * a mouse study in 2025 found that reducing expression of Homer1 in prefrontal cortex neurons where attention is based, caused those cells to upregulate GABA receptors-the molecular brakes of the nervous system. This shift created a quieter baseline and more focused bursts of activity when cues appeared: instead of firing indiscriminately, neurons conserved their activity for moments that mattered, enabling more accurate responses. (([[https://www.nature.com/articles/s41593-025-02155-2|2025: Genetic mapping identifies Homer1 as a developmental modifier of attention]]))
  
adhd.txt · Last modified: 2025/12/22 22:14 by gary1

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