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cachexia [2025/08/15 04:07] – [role of the vagal nerve] whcachexia [2026/07/10 08:25] (current) – [role of the vagal nerve] gary1
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   *the resulting hepatic dysfunction amplifies systemic inflammation, driving the cachectic symptoms that afflict many cancer patients   *the resulting hepatic dysfunction amplifies systemic inflammation, driving the cachectic symptoms that afflict many cancer patients
   *restoring vagal function by targeting the right cervical vagus nerve reestablished normal liver metabolism, reduced systemic inflammation, and alleviated cachexia's clinical manifestations (([[https://www.cell.com/cell/abstract/S0092-8674(25)00805-0|Cell 2025: Vagal blockade of the brain-liver axis deters cancer-associated cachexia]]))   *restoring vagal function by targeting the right cervical vagus nerve reestablished normal liver metabolism, reduced systemic inflammation, and alleviated cachexia's clinical manifestations (([[https://www.cell.com/cell/abstract/S0092-8674(25)00805-0|Cell 2025: Vagal blockade of the brain-liver axis deters cancer-associated cachexia]]))
 +  *a 2026 study on mice suggests that lung cancer produces more local prostaglandin E2 which then activates vagal nerve activity via lung neurons which appears to mediate cachexia and this can be **remedied by blocking PGE2 production or blocking the the vagal nerve** (([[https://www.science.org/doi/10.1126/science.adz4196|2026: A dietary switch promotes sensory neuron–dependent cancer-associated cachexia]]))
  
cachexia.txt · Last modified: 2026/07/10 08:25 by gary1

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