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--- caffeine [2026/07/26 07:17] – [Caffeine doses by average serving sizes] gary1
+++ caffeine [2026/09/02 08:30] (current) – [pharmacokinetics] gary1
@@ Line 34: / Line 34: @@
   *metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme.
     *individuals who are homozygous for the CYP1A2*1A allele are "rapid" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "slow" caffeine metabolizers.
+    *the genetic variant of CYP1A2, rs762551, alters inducibility: AA carriers are classified as fast metabolizers, AC carriers as intermediate metabolizers, and CC carriers as slow metabolizers, with slower metabolism resulting in prolonged systemic exposure to caffeine.
   *half life in adults is generally 3-4hrs but increased to 5-10hrs in women on the [[OCP]], and 9-11hrs in pregnant women.
   *severe liver disease may result in half life of 96hrs.