gene_regulation
Differences
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| gene_regulation [2026/05/25 15:28] – [Eukaryotic gene regulation] gary1 | gene_regulation [2026/10/24 23:31] (current) – [Eukaryotic gene regulation] gary1 | ||
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| * [[miRNAs]] | * [[miRNAs]] | ||
| * can also bind to the RNA molecule along with a ribonucleoprotein complex called the **RNA-induced silencing complex (RISC)** which rapidly degrades the target mRNA | * can also bind to the RNA molecule along with a ribonucleoprotein complex called the **RNA-induced silencing complex (RISC)** which rapidly degrades the target mRNA | ||
| + | ***adenosine deaminases acting on RNA (ADARs) to produce different proteins** | ||
| + | * a widespread post-transcriptional modification that converts adenosine to inosine (A to I) a mimic for guanosine during translation (especially in squid which have been shown to edit almost 8000 sites in 2,091 squid proteins)(([[https:// | ||
| + | * ADARs can thus alter protein-coding sequences, splice sites, microRNA (miRNA) interactions, | ||
| + | * in most animals, editing is limited and acts as a highly specialized regulatory buffer that fine-tunes RNA function on top of DNA-encoded sequences | ||
| + | * only a small number of RNA editing events in mammals are known to exert physiological effects, such as the Q/R recoding of the AMPA receptor subunit GluA2, I/V recoding of Kv1.1, and R/R recoding of NEIL1 | ||
| * **translational** | * **translational** | ||
| * mRNA binding to the ribosome | * mRNA binding to the ribosome | ||
gene_regulation.txt · Last modified: by gary1