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--- git_microbiome [2025/11/05 10:15] – [Introduction] gary1
+++ git_microbiome [2025/11/05 22:34] (current) – [Introduction] gary1
@@ Line 19: / Line 19: @@
       * "gut microbiota modulation of the gut immune system plays a significant role in the development and training of the systemic immune system and influences the outcome of extragastrointestinal diseases like influenza, HIV, diabetes, multiple sclerosis, and autoimmune arthritis, among others. For example, segmented filamentous bacteria induce the differentiation of Peyer’s patch CD4 T cells into follicular T helper cells, which enter circulation and regulate germinal center formation in auto-antibody production in systemic lymph nodes" (([[https://www.nature.com/articles/s41467-023-42235-0|Nature 2023: Gut Bacteroides act in a microbial consortium to cause susceptibility to severe malaria ]]))
   *the microbiome can remove some toxins
+    * various species can metabolize dietary nitrates and nitrites and prevent the formation of cancer-causing compounds called nitrosamines - particularly, //E. coli//, and to a lesser extent, species of the genera //Lactobacillus//, //Bacteroides// and //Phocaeicol//(([[https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.70299|2025: Distribution and activity of nitrate and nitrite reductases in the microbiota of the human intestinal tract]]))
     * //Bacteroides uniformis// in particular appears to have a strong ability to absorb [[pfas_pfoa|PFAS forever toxins]] from the body which are then excreted in faeces
   * when the gut microbiome is severely disrupted as in antibiotic therapy, there is a risk of life threatening toxic megacolon due to overgrowth of colonic [[clostridium_difficile]]