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--- glymphatic_system [2026/05/28 08:45] – created gary1
+++ glymphatic_system [2026/06/22 23:48] (current) – [Introduction] gary1
@@ Line 18: / Line 18: @@
   *glymphatic clearance can be manipulated by sleep deprivation, cisterna magna puncture, acetazolamide or genetic deletion of AQP4 channels
   *it has been proposed that glymphatic dysfunction is the central cause of [[n_delirium]](([[https://www.nature.com/articles/s41582-026-01194-y|2026: Glymphatic dysfunction: a unifying hypothesis for delirium]]))
+  *variants of the aquaporin‑4 (AQP4) gene, which helps regulate the glymphatic system may increase risk of [[dementia|Alzheimer's disease]] - those carrying certain AQP4 variants showed faster grey matter loss when they reported shorter sleep(([[https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71516|2026: Evidence for direct and sleep-moderated relationships between aquaporin-4 genetic variants and Alzheimer's disease phenotypes]]))