gut-brain
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| gut-brain [2025/02/15 22:37] – [Introduction] gary1 | gut-brain [2025/11/05 10:11] (current) – [Gut microbiota signalling] gary1 | ||
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| * SCFAs are known to play a critical role in food intake regulation | * SCFAs are known to play a critical role in food intake regulation | ||
| * via binding to FFAR2 and FFAR3 in L-cells, these metabolites stimulate the release of satiety peptides, such as PYY and GLP-1 | * via binding to FFAR2 and FFAR3 in L-cells, these metabolites stimulate the release of satiety peptides, such as PYY and GLP-1 | ||
| + | * SCFAs have been implicated in improving sleep(([[https:// | ||
| + | * sodium butyrate supplementation enhances sleep quality in patients with active ulcerative colitis, while animal studies demonstrate that butyrate alleviates inflammatory responses and memory impairment induced by sleep deprivation | ||
| * other important bacterial metabolites are: | * other important bacterial metabolites are: | ||
| * secondary bile acids | * secondary bile acids | ||
| * can promote the release of GLP-1 by the activation of protein-coupled bile acid receptors in L-cells, thus affecting food intake | * can promote the release of GLP-1 by the activation of protein-coupled bile acid receptors in L-cells, thus affecting food intake | ||
| + | * chronic insomnia associates with elevated levels of primary bile acids including murocholic acid and norcholic acid, alongside reduced secondary bile acids such as isolithocholic acid, lithocholic acid, and ursodeoxycholic acid (([[https:// | ||
| * **tryptophan** | * **tryptophan** | ||
| * plays a central role in gastric motility-mediated appetite regulation in mammals as well as being the precursor to serotonin | * plays a central role in gastric motility-mediated appetite regulation in mammals as well as being the precursor to serotonin | ||
gut-brain.txt · Last modified: 2025/11/05 10:11 by gary1