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--- n_delirium [2026/05/01 23:57] – [introduction] gary1
+++ n_delirium [2026/08/18 23:51] (current) – [introduction] gary1
@@ Line 12: / Line 12: @@
   *it should be differentiated from a primary psychiatric diagnosis such as a psychosis, or from drug or alcohol related withdrawal states.
   *it has been proposed that glymphatic dysfunction is the central cause of delirium(([[https://www.nature.com/articles/s41582-026-01194-y|2026: Glymphatic dysfunction: a unifying hypothesis for delirium]]))
+  *post-operative delirium may increase risk of dementia
+    * thought go be due to stresses altering two "epigenetic" mechanisms  that impair of BDNF–ARC signaling that control whether genes are turned on or off. The resulting changes impaired the brain's ability to form memories and learn new information while also disrupting the internal clock that regulates healthy sleep patterns. This appears to be prevented by vorinostat.(([[https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71556|2026: Epigenetically driven impairment of BDNF–ARC signaling contributes to circadian and cognitive disarray in a mouse model of postoperative delirium]]))
 =====is it delirium?=====