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neo_oropharyngeal [2026/05/23 16:36] – [introduction] gary1neo_oropharyngeal [2026/05/23 16:36] (current) – [introduction] gary1
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       *5 year survival rate 45-50% for stage III/IV((NEJM 363:1 July 1 2010))       *5 year survival rate 45-50% for stage III/IV((NEJM 363:1 July 1 2010))
       *a 2013 study showed 55% patients with HPV-positive cancers were alive two years after a recurrence, compared with 28% of those with HPV-negative cancers       *a 2013 study showed 55% patients with HPV-positive cancers were alive two years after a recurrence, compared with 28% of those with HPV-negative cancers
-    ***two groups of no identifiable risk factor (NIRF), hpv-negative, no alcohol or tobacco, and probably mediated by endogenous factors**(([[https://www.nature.com/articles/s41368-026-00437-4|2026: Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns]]))+    ***for oral cavity squamous cell carcinomas (OCSCC), two groups of no identifiable risk factor (NIRF), hpv-negative, no alcohol or tobacco, and probably mediated by endogenous factors**(([[https://www.nature.com/articles/s41368-026-00437-4|2026: Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns]]))
       *aging-related SBS1 endogenous mutation group       *aging-related SBS1 endogenous mutation group
       *APOBEC-associated signatures (SBS2 and SBS13)        *APOBEC-associated signatures (SBS2 and SBS13) 
  
  
neo_oropharyngeal.txt · Last modified: 2026/05/23 16:36 by gary1

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