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ocp [2025/10/27 22:05] gary1ocp [2026/07/07 23:53] (current) – [other effects of combined OCP's:] gary1
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   *helps reduce risk of ovarian Ca   *helps reduce risk of ovarian Ca
 ===other combined effects=== ===other combined effects===
-  *altered hepatoc metabolism of other drugs, eg.:+  *altered hepatic metabolism of other drugs, eg.:
     *can double the half-life of [[methylxanthines|caffeine]]     *can double the half-life of [[methylxanthines|caffeine]]
 +  *altered serum levels of hormones:
 +    * oral estrogens raise corticosteroid-binding globulin (CBG) levels, leading to increased serum total cortisol concentrations
 +      * serum corticosteroid-binding globulin (CBG) and total cortisol levels decreased significantly and normalised by 4 weeks in women after discontinuation combined OCP(([[https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgag249/8715179?login=false|2026: Prospective evaluation of the effect of stopping estrogen-containing contraceptives on serum CBG and cortisol levels]]))
   *seems each decade of OCP use results in 20-30% more plaque formation and thus increasing [[atherosclerosis]]   *seems each decade of OCP use results in 20-30% more plaque formation and thus increasing [[atherosclerosis]]
     *see [[http://www.abc.net.au/science/news/stories/2007/2085475.htm?health]]     *see [[http://www.abc.net.au/science/news/stories/2007/2085475.htm?health]]
ocp.txt · Last modified: 2026/07/07 23:53 by gary1

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