orexin
Differences
This shows you the differences between two versions of the page.
| Both sides previous revisionPrevious revision | |||
| orexin [2026/08/03 10:32] – [Orexin receptors] gary1 | orexin [2026/08/03 10:50] (current) – gary1 | ||
|---|---|---|---|
| Line 33: | Line 33: | ||
| =====Orexin receptors===== | =====Orexin receptors===== | ||
| - | *two orexin receptors - one for each type of orexin | + | *two orexin receptors |
| *these are strongly conserved across mammals, with 94% identity in the amino acid sequences between humans and rats | *these are strongly conserved across mammals, with 94% identity in the amino acid sequences between humans and rats | ||
| - | ====orexin-A receptors==== | + | *OX1R and OX2R mRNA is widely expressed in the brain in a pattern similar to that of orexin |
| - | ====orexin-B receptors==== | + | |
| + | ====orexin-A OX1R receptors==== | ||
| + | |||
| + | ====orexin-B | ||
| ====dual orexin-A and orexin-B antagonists (Doras)===== | ====dual orexin-A and orexin-B antagonists (Doras)===== | ||
| *see [[doras]] | *see [[doras]] | ||
| *in trial to Mx narcolepsy | *in trial to Mx narcolepsy | ||
| + | |||
| + | =====Orexin and narcolepsy===== | ||
| + | *those with the full narcolepsy phenotype have a ~90% loss of the orexin-producing neurons in addition to a marked reduction in CSF levels of orexin-A | ||
orexin.txt · Last modified: 2026/08/03 10:50 by gary1