ppis
Differences
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| ppis [2017/11/01 10:01] – created - external edit 127.0.0.1 | ppis [2026/07/31 11:40] (current) – [potential problems of proton pump inhibitors:] gary1 | ||
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| *PPI Rx appears to **increase risk of [[pneumonia]]** by 16-50% and may be responsible for up to 4% of all community acquired pneumonia although causal effect has not yet been proven as other concurrent factors in these patients taking PPIs may be important such as alcohol abuse, morbid obesity, PH [[stroke]], or impaired immunity due to chronic illness. | *PPI Rx appears to **increase risk of [[pneumonia]]** by 16-50% and may be responsible for up to 4% of all community acquired pneumonia although causal effect has not yet been proven as other concurrent factors in these patients taking PPIs may be important such as alcohol abuse, morbid obesity, PH [[stroke]], or impaired immunity due to chronic illness. | ||
| *PPI Rx appears to **increase risk of //Cl. difficile// infection** with an odds ratio of 3.5 (95% CI 2.3-5.2) | *PPI Rx appears to **increase risk of //Cl. difficile// infection** with an odds ratio of 3.5 (95% CI 2.3-5.2) | ||
| - | *achlorhydria | + | *[[hypochlorhydria]] |
| ***potential for risk of [[osteoporosis]]**: | ***potential for risk of [[osteoporosis]]**: | ||
| *An acid environment is needed for insoluble calcium absorption, but the effects of PPI on dietary calcium absorption are uncertain. Increasing dietary calcium intake and taking calcium citrate as a supplement (which does not require gastric acid for absorption) is not established practice for patients who are prescribed acid-suppressing medications. | *An acid environment is needed for insoluble calcium absorption, but the effects of PPI on dietary calcium absorption are uncertain. Increasing dietary calcium intake and taking calcium citrate as a supplement (which does not require gastric acid for absorption) is not established practice for patients who are prescribed acid-suppressing medications. | ||
ppis.txt · Last modified: 2026/07/31 11:40 by gary1