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--- prv [2025/09/08 12:11] – [clinical features] gary1
+++ prv [2026/05/10 21:04] (current) – [introduction] wh
@@ Line 11: / Line 11: @@
   *incidences of polycythaemia vera, [[essential_thrombocytosis]], and myelofibrosis were 10x higher among Ashkenazi Jews in northern Israel than in persons of Arabic descent in the region.
   *most cases occur in those 40-60 yrs old and are due to acquired (not inherited) mutations in genes such as [[JAK|JAK2]], TET2
+  *often following a pre-malignant period ([[CHIP]]))
   *rarely, risk of PRV may be inherited in an autosomal dominant manner