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--- psilocybin [2026/06/25 07:36] – [Pharmacology] gary1
+++ psilocybin [2026/08/20 14:48] (current) – [Pharmacology] gary1
@@ Line 65: / Line 65: @@
       * causes significant disruptions in brain functional connectivity (FC), particularly in the default mode network, linked to subjective experiences and lasting for weeks, which may underlie its therapeutic effects(([[https://www.nature.com/articles/s41586-024-07624-5|Nature 2024. Psilocybin desynchronizes the human brain]])). Via serotonin 2A (5-HT2A) receptor activation, it can induce significant acute and persistent changes in self, time, and space perception.
       * can strengthen some connections and weaken others but this may be partly dependent upon what is being attended to during a session - one dose of psilocybin induced structural remodeling of dendritic spines in the medial frontal cortex in mice and its effect on connectivity is network specific, strengthening the routing of inputs from perceptual and medial regions (homolog of the default mode network) to subcortical targets while weakening inputs that are part of cortico-cortical recurrent loops, and silencing a presynaptic region during psilocybin administration disrupts the rewiring. (([[https://www.cell.com/cell/fulltext/S0092-8674(25)01305-4|2026: Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks]])) - hence this could be manipulated by third parties for better or worse
+      * see also: [[https://www.nature.com/articles/s41586-026-10910-z|2026: Monash Uni study: Psychedelics align brain activity with context]]
     * associated with decreases in cerebral blood flow and blood oxygen level dependent signaling
     * alters temporal processing