pulmonary_hypertension
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| pulmonary_hypertension [2026/09/03 13:40] – [introduction] gary1 | pulmonary_hypertension [2026/09/03 13:41] (current) – [introduction] gary1 | ||
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| *defined as a mean pulmonary arterial pressure greater than 25 mm Hg at rest or greater than 30 mm Hg during exercise | *defined as a mean pulmonary arterial pressure greater than 25 mm Hg at rest or greater than 30 mm Hg during exercise | ||
| *characterized by a progressive and sustained increase in pulmonary vascular resistance that eventually leads to RVF and [[cor_pulmonale]] | *characterized by a progressive and sustained increase in pulmonary vascular resistance that eventually leads to RVF and [[cor_pulmonale]] | ||
| - | *it appears it may in part at least, be caused by elevated levels of microRNA-224 which orchestrates BMP and TGFβ signaling and thus acts as a regulator of pulmonary vascular remodeling, and blocking this in animal models appears to help reverse the condition(([[https:// | + | *it appears it may, in part at least, be caused by elevated levels of microRNA-224 which orchestrates BMP and TGFβ signaling and thus acts as a regulator of pulmonary vascular remodeling, and blocking this in animal models appears to help reverse the condition(([[https:// |
| =====clinical features===== | =====clinical features===== | ||
pulmonary_hypertension.txt · Last modified: 2026/09/03 13:41 by gary1