steatohepatitis
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| steatohepatitis [2025/12/18 21:52] – [non-alcoholic steatohepatitis (NASH)] gary1 | steatohepatitis [2025/12/18 21:53] (current) – [non-alcoholic steatohepatitis (NASH)] gary1 | ||
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| *two sub groups: | *two sub groups: | ||
| * metabolic dysfunction-associated steatotic liver disease (**MASLD**) | * metabolic dysfunction-associated steatotic liver disease (**MASLD**) | ||
| - | * findings from citrin deficiency suggests that in lean people it may be due to the accumulation of glycerol-3-phosphate (G3P) that activates carbohydrate response element-binding protein (ChREBP), a protein that turns on fat synthesis genes and induces fibroblast growth factor 21 (FGF21). FGF21 is normally released into circulation by the liver in response to fasting, ethanol, exercise, ketogenic diet, simple carbohydrates (esp. fructose), refeeding, obesity, type 2 DM, and mitochondrial disease, and has multiple sites of action including specific β-klotho-expressing regions of the brain, where FGF21 functions to restrain the intake of sweets and ethanol, and the periphery, where it increases energy expenditure and body temperature. (([[https:// | + | * findings from citrin deficiency suggests that in lean people it may be due to the accumulation of glycerol-3-phosphate (G3P) that activates carbohydrate response element-binding protein (ChREBP), a protein that turns on fat synthesis genes and induces fibroblast growth factor 21 (FGF21). FGF21 is normally released into circulation by the liver in response to fasting, ethanol, exercise, ketogenic diet, simple carbohydrates (esp. fructose), refeeding, obesity, type 2 DM, and mitochondrial disease, and has multiple sites of action including specific β-klotho-expressing regions of the brain, where FGF21 functions to restrain the intake of sweets and ethanol, and the periphery, where it increases energy expenditure and body temperature. Fasting, refeeding, ketogenic diet, simple carbohydrates, |
| * metabolic dysfunction-associated steatohepatitis (**MASH**) | * metabolic dysfunction-associated steatohepatitis (**MASH**) | ||
| * appears to substantially improve with [[glp-1analogs]] | * appears to substantially improve with [[glp-1analogs]] | ||
steatohepatitis.txt · Last modified: 2025/12/18 21:53 by gary1