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stroke_antithromboticrx [2026/08/31 10:33] – [balance the stroke prevention benefits with risk of major bleeding] gary1stroke_antithromboticrx [2026/08/31 10:33] (current) – [new AMI and non-valvular AF] gary1
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   *for patients who have an AMI and are in AF:   *for patients who have an AMI and are in AF:
     * patients who have recently had a myocardial infarction receive antiplatelet therapy, in particular the combination of aspirin and a potent P2Y12 inhibitor, to reduce their risk of another ischemic event     * patients who have recently had a myocardial infarction receive antiplatelet therapy, in particular the combination of aspirin and a potent P2Y12 inhibitor, to reduce their risk of another ischemic event
-    * HOWEVER, avoid using prasugrel or ticagrelor with a DOAC (the experimental arm in this study) as the 2026 EPIDAURUS trial comparing this with DOAC plus clopidogrel with in-hospital aspirin control group for a 1 month duration post AMI was terminated early as there was no evidence of benefit of the experimental arm and a 3.5x risk of significant bleeding(([[https://www.news-medical.net/news/20260829/Potent-antiplatelet-therapy-increases-bleeding-risk-after-heart-attack-in-AF-patients.aspx]]))+    * HOWEVER, **avoid using prasugrel or ticagrelor with a DOAC** (the experimental arm in this study) as the 2026 EPIDAURUS trial comparing this with DOAC plus clopidogrel with in-hospital aspirin control group for a 1 month duration post AMI was terminated early as there was no evidence of benefit of the experimental arm and a 3.5x risk of significant bleeding(([[https://www.news-medical.net/news/20260829/Potent-antiplatelet-therapy-increases-bleeding-risk-after-heart-attack-in-AF-patients.aspx]]))
  
  
stroke_antithromboticrx.txt · Last modified: 2026/08/31 10:33 by gary1

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