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| syphilis [2026/01/23 05:19] – [Epidemiology] gary1 | syphilis [2026/01/23 05:24] (current) – [Epidemiology] gary1 |
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| =====Epidemiology==== | =====Epidemiology==== |
| *appears to have arisen in South America and brought to Europe in the late 15th century | *appears to have arisen in South America and brought to Europe in the late 15th century by Columbus' crew |
| *the origins and early diversification of Treponema pallidum subspecies, which cause syphilis, yaws, and bejel, remain poorly resolved | *the origins and early diversification of Treponema pallidum subspecies, which cause syphilis, yaws, and bejel, remain poorly resolved |
| * a 5,500-year-old Treponema genome was recovered from Middle Holocene-age human hunter-gatherer remains from Colombia, although this TE1-3 strain is genetically diverse and distinct from modern strains and is thought to have diverged from their line 13,700yrs ago but possesses the T. pallidum virulence-associated genes, suggesting conserved pathogenic capacity (([[https://www.science.org/doi/10.1126/science.adw3020|2026: A 5500-year-old Treponema pallidum genome from Sabana de Bogotá, Colombia]])) | * a 5,500-year-old Treponema genome was recovered from Middle Holocene-age human hunter-gatherer remains from Colombia, although this TE1-3 strain is genetically diverse and distinct from modern strains and is thought to have diverged from their line 13,700yrs ago but possesses the T. pallidum virulence-associated genes, suggesting conserved pathogenic capacity (([[https://www.science.org/doi/10.1126/science.adw3020|2026: A 5500-year-old Treponema pallidum genome from Sabana de Bogotá, Colombia]])) |
