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thrombophilia

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thrombophilia [2023/10/19 21:54] – [introduction] gary1thrombophilia [2026/07/07 10:48] (current) – [introduction] gary1
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   *other haematologic conditions predisposing to thrombosis:   *other haematologic conditions predisposing to thrombosis:
     * [[JAK|JAK2 V617F mutation]] with or without [[essential_thrombocytosis]] or overt myeloproliferative neoplasm mainly associated with splanchnic vein or cerebral vein thromboses     * [[JAK|JAK2 V617F mutation]] with or without [[essential_thrombocytosis]] or overt myeloproliferative neoplasm mainly associated with splanchnic vein or cerebral vein thromboses
 +    * a 2026 study suggests another 494 genes are associated with thrombophilic risk(([[https://www.jthjournal.org/article/S1538-7836(26)00338-7/abstract|2026: Gene expression integration and similarity score–based modeling improve risk stratification in idiopathic venous thrombophilia]]))
   * **high VTE polygenic risk score people**   * **high VTE polygenic risk score people**
     * polygenic risk score for DVT includes rs6025 (FVL) (effect allele T; allele frequency, 0.02) in the F5 gene and rs1799963 (PTM) (effect allele A; allele frequency, 0.01) in the F2 gene      * polygenic risk score for DVT includes rs6025 (FVL) (effect allele T; allele frequency, 0.02) in the F5 gene and rs1799963 (PTM) (effect allele A; allele frequency, 0.01) in the F2 gene 
thrombophilia.txt · Last modified: 2026/07/07 10:48 by gary1

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