toxoplasmosis
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| toxoplasmosis [2026/08/12 10:13] – [Life cycle] gary1 | toxoplasmosis [2026/09/27 14:50] (current) – [Life cycle] gary1 | ||
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| *unlike other forms of the parasites, the oocytes can survive for long periods in water | *unlike other forms of the parasites, the oocytes can survive for long periods in water | ||
| *the oocytes are ingested by other mammalian hosts (including marine) which then excyst and invade the host as tachyzoites which may become tissue cysts in the form of bradyzoites which are very resistant to antimicrobial medications | *the oocytes are ingested by other mammalian hosts (including marine) which then excyst and invade the host as tachyzoites which may become tissue cysts in the form of bradyzoites which are very resistant to antimicrobial medications | ||
| + | * on finding a potential host cell, three Toxoplasma proteins, collectively known as the MIC1/4/6 complex, that recognize particular glycans on the host-cell surface and appear to gather glycosylated host proteins together, while cholesterol helps make that reorganization possible and creates the right conditions to allow Toxoplasma to release specialized organelles called rhoptries into the host cell which contain proteins that manipulate the host cell and help establish receptors to allow the Toxoplasma to enter the host cell(([[https:// | ||
| + | * the sugars recognized by the MIC1/4/6 complex are widely distributed across mammalian tissues, and the complex can recognize more than one glycan type | ||
| * the protein TgPRO produced by Toxoplasma, allows Toxoplasma packed into a tissue cysts to manage oxidative stress that can damage cells by controlling genes involved in energy production and iron use - it appears TgPRO supports parasite growth in the naturally dense environment of a chronic-stage cyst(([[https:// | * the protein TgPRO produced by Toxoplasma, allows Toxoplasma packed into a tissue cysts to manage oxidative stress that can damage cells by controlling genes involved in energy production and iron use - it appears TgPRO supports parasite growth in the naturally dense environment of a chronic-stage cyst(([[https:// | ||
| *oocytes also excyst in tissues after parenteral innoculation | *oocytes also excyst in tissues after parenteral innoculation | ||
toxoplasmosis.txt · Last modified: 2026/09/27 14:50 by gary1