antibiotics for Rx of Staph. aureus

see also:

• antibiotics
• staphylococcus
• wikipedia - MRSA

• flucloxacillin
• dicloxacillin
• methicillin
• penicillins combined with beta lactamase inhibitors such as clavulanic acid, sulbactam, tazobactam
  • eg. amoxycillin with clavulanic acid (Augmentin Duo Forte)

• cephalexin
• cephazolin

• erythromycin
• quinolones such as ciprofloxacin

• MRSA contains a gene, mecA, which stops β-lactam antibiotics from inactivating the enzymes (transpeptidases) that are critical to cell wall synthesis
• use of fluoroquinolones is associated with significantly increased risk of colonisation with MRSA
• community acquired MRSA is a hybrid of hospital MRSA and community Staph and tends to be more virulent, although easier to treat than hospital MRSA
  • CA-MRSA may respond to co-trimoxazole, tetracyclines or clindamycin but is usually treated with vancomycin
• vancomycin
• teicoplanin
  • a structural congener of vancomycin that has a similar activity spectrum but a longer half-life

• linezolid
• quinupristin/dalfopristin(synercid)
• daptomycin
  • This antibiotic is not effective for left-sided endocarditis, or for pneumonia because it binds to surfactant and is inactivated.
  • The efficacy of daptomycin in patients with prosthetic heart valves has not been demonstrated.
  • see also Australian Prescriber article
• tigecycline