pooled analysis of six major clinical trials in 2002 assessed second generation coronary stents with long term aspirin and 4 weeks ticlodipine:
Clinically relevant restenosis occurred in only about one-half of patients with angiographic restenosis (defined as ≥50 percent diameter stenosis).
The predictors of both clinical and angiographic restenosis were the same (smaller posttreatment lumen diameter, stent length, and diabetes).
at 1 year, target lesion revascularisation was performed in 12% and target vessel revascularisation in 14.1% which were higher than at 6 months demonstrating a higher than expected delayed presentation.
most clinically significant restenosis with second generation stents become clinically evident within the first 6-12 months.
after one year, recurrent ischemia is more likely to be due to new or progressive disease at another site rather than restenosis.