a linear association between the Caprini RAM and risk of VTE was noted up to a Caprini score of 10
HOWEVER it was UNABLE to identify a subset of non-ICU medical inpatients who would benefit from pharmacologic prophylaxis
strongest independent predictors of VTE were central venous catheter on admission, PH or FH VTE, admission or treatment of cancer in the past year, and current immobility
Even among patients with Caprini scores ≥ 5 who did not receive pharmacologic prophylaxis, the 90-day rate of VTE was less than 2.0 per 10,000 patient-days and thus because rates of VTE are so low, the findings raise questions regarding existing VTE prevention strategies that often advocate for routine use of pharmacologic prophylaxis in hospitalized medical patients
not able to identify a clear Caprini threshold that effectively isolates a patient sub-group that may benefit from pharmacologic VTE prophylaxis
administration of pharmacologic prophylaxis to nearly 500 non-surgical, non-ICU, medical patients with Caprini scores ≥ 5 would be needed to prevent a single VTE event - VTE event rate without prophylaxis is 1.6% and VTE event rate with prophylaxis 1.4% and this group constitutes 80% of these inpatients