a rare type of GIT tumour (some are benign, some are malignant) believed to originate in cells found between muscle layers of the gastro-intestinal tract, called Interstitial cells of Cajal (ICC) and generally grow outwards
50-60% arise in the stomach
30-40% arise in small intestines
Aetiology
increasing age
genetic risk factors
Neurofibromatosis type 1
Carney Triad
a rare syndrome defined by the coexistence of three specific tumours and typically affecting young people
Clinical features
usually asymptomatic
may cause pain, bloating, fatigue, occult or overt GIT bleeding
Diagnosis
may be picked up on gastroscopy or CT scan
biopsy to confirm benign vs malignant status
Treatment
most are treated with surgical excision
imatinib is used to treat GIST that cannot be removed by surgery