Serum glial fibrillary acidic protein levels are 97% accurate up to 7 days post injury of detecting brain injury such as concussion… may lead to a new biomarker that could reduce CT scans 1)
NICE 2014 indications for head CT scan within 1 hour
if ONE or MORE of
suspicion of NAI
post-traumatic seizure and no PH epilepsy
GCS < 14 on arrival (<15 if < 1 yr old)
GCS < 15 at 2hrs
signs of base of skull #
focal neurology
suspected open # or depressed skull #
tense fontanelle
swelling / bruise / laceration > 5cm in those under 1 yr old
JAMA Neurology 2016. Brophy G, Welch R, Papa L, et al. Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury.