insulin resistance is when cells in your muscles, fat, and liver don’t respond well to insulin and can’t easily take up glucose from blood.
as a result, your pancreas makes more insulin to help glucose enter your cells
as capacity of the pancreas to secrete insulin starts to become inadequate, blood sugars begin to rise and patients become “pre-diabetic” and can eventually develop type 2 diabetes mellitus
insulin resistance is a key component of the “metabolic syndrome” as well as obesity, inadequate aerobic exertion and can be evidenced by:
elevated fasting insulin levels
fasting hypertriglyceridaemia
development of skin tags or seborrheic warts
Risk factors
genetic factors
tends to be familial (this also has environmental/cultural factors as well as epigenetic factors)