ovarian hyperstimulation syndrome (OHSS)

see also:

• a complication of IVF therapies which although most cases are mild, can result in severe illness and generally lasts 1-2 weeks

• ovarian enlargement to 5-12cm
• ascites with mild abdominal distension
• abdominal pain
• nausea
• diarrhoea
• mildly raised D-Dimer pathology test

• additional features may include:
  • ascites
  • hematocrit > 45%
  • WBC > 15,000
  • oliguria
  • creatinine 1.0-1.5 mg/dl
  • creatinine clearance > 50 ml/min
  • liver dysfunction
  • anasarca.

• may include:
  • enlarged ovary
  • tense ascites with hydrothorax and pericardial effusion
  • hematocrit > 55%
  • WBC > 25,000
  • oligoanuria,
  • creatinine > 1.6 mg/dl
  • creatinine clearance < 50 ml/min
  • kidney failure
  • thromboembolic phenomena
  • ARDS

• may be complicated by:
  • ovarian torsion
  • ovarian rupture
  • venous thromboembolism
  • acute respiratory distress syndrome
  • electrolytes imbalance
  • thrombophlebitis
  • chronic kidney disease