Table of Contents
Relaxin
Introduction
Actions:
Relaxin
see also
gynaecology
Introduction
Polypeptide similar to insulin, controlled by 2 gene sites, mainly produced by corpus luteum of pregnancy, but also by chorion & decidua.
Levels rise early in 1st TM & stay high until mid-pregnancy & become very high during labour & become almost indetectable within 3 days post-partum;
Receptor sites identified:
pubic symphysis, myometrium, cervix, placenta, breast tissues; skin;
Actions:
Softens connective tissue:
increased water content of ground substance?
activation of collagenolytic system?
activation of fibroplasts?
other actions
Aids implantation;
Aids cervical ripening prior to labour;
Augments the breast changes of pregnancy;
Improves sperm motility;