Table of Contents
introduction
vasopressin-V2 receptor antagonists
tolvaptan
vasopressin receptor antagonists
see also:
argipressin (vasopressin / ADH)
introduction
vasopressin-V2 receptor antagonists have been used to Rx:
dilutional hyponatraemia
volume overload in
congestive cardiac failure
reducing rate of progression of
ADPKD
vasopressin-V2 receptor antagonists
tolvaptan
appears to substantially reduce disease progression in patients with
ADPKD
however almost 25% of patients discontinued Rx due to adverse effects such as aquaresis (excretion of electrolyte-free water) and hepatic adverse events
see NEJM 367;25. Dec 20th, 2012. pp2407-2418