neo_vulval
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Table of Contents
vulval cancer
introduction
- like cervical cancer, vulval carcinoma is associated with human papilloma virus (HPV) infection
- striking increase in vulval intraepithelial neoplasia (VIN) since 1980 with the median age of presentation falling to the mid-30's
- at least 2/3rds of these women smoke cigarettes
- nearly 50% have PH of SIL/CIN
- many of the younger women have HPV DNA on biopsy
- other risk factors:
- lichen sclerosis - thin, white, wrinkled patches, mainly genital / anal areas esp. in post-menopausal women, often itchy esp. at night, and is a risk factor for vulval cancer - this risk can be reduced by long term topical steroids such as clobetasol
clinical presentations
- vulvar pruritus
- vulval lump
- warty vulvar lesion which may be unifocal or multifocal, flat, papular or in extensive plaques, pigmented, white or red
- transit times from VIN III to invasion is less than 8yrs in nearly all studies, thus any gross lesion should be biopsied or referred to a vulvar specialist
neo_vulval.1777561802.txt.gz · Last modified: 2026/04/30 15:10 by gary1