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adaptive_immunity [2026/01/07 22:57] – [T lymphocytes] gary1adaptive_immunity [2026/05/25 08:30] (current) – [T lymphocytes] gary1
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     * the gene Malat1 is a critical player in regulating immune responses in female TH2 cells, but not in males. Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2. This genetic difference may partly explain why women have a higher prevalence of auto-immune diseases(([[https://academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf177/8241326?login=false|2025: Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2]])) (perhaps along with post-pregnancy chimeric stem cells from foetus which may persist for decades)     * the gene Malat1 is a critical player in regulating immune responses in female TH2 cells, but not in males. Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2. This genetic difference may partly explain why women have a higher prevalence of auto-immune diseases(([[https://academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf177/8241326?login=false|2025: Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2]])) (perhaps along with post-pregnancy chimeric stem cells from foetus which may persist for decades)
   ***CD8+ cytotoxic killer T-cells**   ***CD8+ cytotoxic killer T-cells**
 +    * not to be confused with natural killer cells (NK) which are part of the [[innate_immunity]]
     * respond to cells with HLA class I bound antigens presented on the surface of antigen presenting cells     * respond to cells with HLA class I bound antigens presented on the surface of antigen presenting cells
     * it seems dietary trans-vaccenic acid (from milk, lamb or beef) reprograms CD8+ T cells and improves anti-tumour immunity (([[https://www.nature.com/articles/s41586-023-06749-3|Nature 2023: Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity]]))     * it seems dietary trans-vaccenic acid (from milk, lamb or beef) reprograms CD8+ T cells and improves anti-tumour immunity (([[https://www.nature.com/articles/s41586-023-06749-3|Nature 2023: Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity]]))
adaptive_immunity.txt · Last modified: 2026/05/25 08:30 by gary1

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