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dpp1inhib [2026/01/29 20:48] – [Introduction] gary1dpp1inhib [2026/01/29 20:50] (current) – [DPP-1 inhibitors] gary1
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 =====DPP-1 inhibitors===== =====DPP-1 inhibitors=====
   ***brensocatib (Brinsupri)**   ***brensocatib (Brinsupri)**
-    * an oral small-molecule inhibitor of dipeptidyl peptidase 1 (DPP1) — approved for Rx of non-cystic fibrosis bronchiectasis by FDA in 2025+    * an oral small-molecule inhibitor of dipeptidyl peptidase 1 (DPP1) — approved for Rx of non-cystic fibrosis bronchiectasis by FDA in 2025 but not yet approved in Australia as of Jan 2026
     * did not improve clinical status at day 29 in patients hospitalised with COVID-19, in fact, these patients were clinically worse(([[https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00261-2/fulltext|2022: Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial]]))     * did not improve clinical status at day 29 in patients hospitalised with COVID-19, in fact, these patients were clinically worse(([[https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00261-2/fulltext|2022: Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial]]))
  
dpp1inhib.txt · Last modified: 2026/01/29 20:50 by gary1

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