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| gene_regulation [2026/05/25 08:40] – [Eukaryotic gene regulation] gary1 | gene_regulation [2026/05/25 08:40] (current) – [Eukaryotic gene regulation] gary1 |
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| * enzyme inhibition mechanisms | * enzyme inhibition mechanisms |
| * activity and/or stability of proteins can also be regulated by adding functional groups, such as methyl, phosphate, or acetyl groups | * activity and/or stability of proteins can also be regulated by adding functional groups, such as methyl, phosphate, or acetyl groups |
| * m<sup>6</sup>A, m<sup>1</sup>A, and m<sup>5</sup>C modifications play key roles to act as precise control points, determining how macrophages develop, function, and communicate - by influencing processes such as cytokine production, metabolic activity, and tissue repair, RNA modifications enable immune cells to rapidly adapt to their surroundings(([[https://www.sciencedirect.com/science/article/pii/S2352304225003708?via%3Dihub|2026: RNA modifications in intestinal macrophages: Implications for gut immunity and inflammation]])) | * eg. m<sup>6</sup>A, m<sup>1</sup>A, and m<sup>5</sup>C modifications play key roles to act as precise control points, determining how macrophages develop, function, and communicate - by influencing processes such as cytokine production, metabolic activity, and tissue repair, RNA modifications enable immune cells to rapidly adapt to their surroundings(([[https://www.sciencedirect.com/science/article/pii/S2352304225003708?via%3Dihub|2026: RNA modifications in intestinal macrophages: Implications for gut immunity and inflammation]])) |
| * N6-methyladenosine (m<sup>6</sup>A) methylation | * N6-methyladenosine (m<sup>6</sup>A) methylation |
| * accomplished through an enzymatic reaction known as the m<sup>6</sup>A methyltransferase complex (MTC) which consists of several proteins, including the core enzymes methyltransferase-like 3 (METTL3) and METTL14, and cofactors such as Wilms' tumor 1-associating protein (WTAP) and RNA-binding motif protein 15 (RBM15) | * accomplished through an enzymatic reaction known as the m<sup>6</sup>A methyltransferase complex (MTC) which consists of several proteins, including the core enzymes methyltransferase-like 3 (METTL3) and METTL14, and cofactors such as Wilms' tumor 1-associating protein (WTAP) and RNA-binding motif protein 15 (RBM15) |
