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innate_immunity [2026/08/02 08:11] – [detection of pathogens] gary1innate_immunity [2026/08/07 01:35] (current) – [the inflammatory response] gary1
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           * acting as Antigen Presenting Cells, migrate to lymph nodes where they present the processed antigens on their surface to naïve CD8<sup>+</sup> T cells ("cross-presentation"), thereby initiating and shaping a targeted, adaptive immune response           * acting as Antigen Presenting Cells, migrate to lymph nodes where they present the processed antigens on their surface to naïve CD8<sup>+</sup> T cells ("cross-presentation"), thereby initiating and shaping a targeted, adaptive immune response
           * TLSs these organized clusters of immune cells serve as local command centers, or immune "outposts," where the body coordinates attacks against cancer directly within tumors(([[https://www.science.org/doi/10.1126/science.ady1678|2026: Dendritic cells control tertiary lymphoid structure development and maintenance in cancer]]))           * TLSs these organized clusters of immune cells serve as local command centers, or immune "outposts," where the body coordinates attacks against cancer directly within tumors(([[https://www.science.org/doi/10.1126/science.ady1678|2026: Dendritic cells control tertiary lymphoid structure development and maintenance in cancer]]))
 +          * activated dendritic cells do not just launch the T-cell mediated anti-tumour immune responses, they are also essential for sustaining them within the tumour itself
         ***conventional dendritic cell type 2 (cDC2s) have a primary role in extracellular threats such as bacteria, fungi and parasites**         ***conventional dendritic cell type 2 (cDC2s) have a primary role in extracellular threats such as bacteria, fungi and parasites**
           * much more abundant than cDSC1s and act as the primary sentinels throughout most mucosal surfaces and peripheral tissues and they present to CD4⁺ Helper T cells           * much more abundant than cDSC1s and act as the primary sentinels throughout most mucosal surfaces and peripheral tissues and they present to CD4⁺ Helper T cells
innate_immunity.txt · Last modified: 2026/08/07 01:35 by gary1

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