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--- lymphopenia [2026/05/27 19:30] – [Introduction] gary1
+++ lymphopenia [2026/05/27 19:31] (current) – [Chronic lymphopenia] gary1
@@ Line 21: / Line 21: @@
 =====Chronic lymphopenia=====
     * 2-4% of adults have levels chronically below 1,000/µL while 20% have levels chronically below 1,500/µL
-    * this may result in impaired immune surveillance: fewer cytotoxic T cells and NK cells to eradicate nascent malignant cells, compounded by restricted T-cell receptor repertoire diversity from homeostatic proliferation. (([[https://oncodaily.com/voices/lymphopenia-457377]]))
+    * this may result in impaired immune surveillance: fewer cytotoxic T cells and killer cells to eradicate nascent malignant cells, compounded by restricted T-cell receptor repertoire diversity from homeostatic proliferation. (([[https://oncodaily.com/voices/lymphopenia-457377]]))
     * appears to be independently linked to all-cause, cancer, and cardiovascular death with ~60% increased all cause mortality over a 9 yr 2020 Copenhagen study (([[https://pubmed.ncbi.nlm.nih.gov/31932337/|2020: Incidental lymphopenia and mortality: a prospective cohort study ]]))
     * appears to be associated with increased risk of hospitalization with infection and increased risk of infection-related death in the general population (([[https://researchprofiles.ku.dk/da/publications/lymphopenia-and-risk-of-infection-and-infection-related-death-in-/|2018: Lymphopenia and risk of infection and infection-related death in 98,344 individuals from a prospective Danish population-based study]]))
     * may be treatable with an IL-15 agonist or increased resistance muscle training which releases IL-15 - both require further study