obesity
Differences
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| obesity [2026/04/25 08:04] – [risks of obesity] gary1 | obesity [2026/04/25 08:04] (current) – [risks of obesity] gary1 | ||
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| * mental health issues | * mental health issues | ||
| * possibly impaired immunity and increased osteoporosis | * possibly impaired immunity and increased osteoporosis | ||
| - | * increased bone marrow fat appears to drive immunosuppression and osteoclast activity via altering the molecular profile of adipocytes, increasing the production of signaling molecules such as MCP-1, which recruits and reshapes myeloid immune cells, markedly increasing PD-L1-expressing myeloid cells within the bone marrow which suppress T-cell activity, and via PD-1 receptors on osteoclast precursors, promoting their differentiation into mature osteoclasts.(([[https:// | + | * increased bone marrow fat in mice appears to drive immunosuppression and osteoclast activity via altering the molecular profile of adipocytes, increasing the production of signaling molecules such as MCP-1, which recruits and reshapes myeloid immune cells, markedly increasing PD-L1-expressing myeloid cells within the bone marrow which suppress T-cell activity, and via PD-1 receptors on osteoclast precursors, promoting their differentiation into mature osteoclasts.(([[https:// |
| * medical iatrogenic risks | * medical iatrogenic risks | ||
| * vascular access issues | * vascular access issues | ||
obesity.txt · Last modified: 2026/04/25 08:04 by gary1