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osa [2026/05/19 22:03] – [Subtypes] whosa [2026/05/19 22:03] (current) – [Subtypes] wh
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   ***"GLP-1 strong responder endotype"**   ***"GLP-1 strong responder endotype"**
     * appear to have much better response to [[GLP-1analogs]] such as tirzepatide which can halve the OSA severity in this subtype compared with other patients with OSA(([[https://www.news-medical.net/news/20260519/Researchers-identity-patients-with-exceptional-tirzepatide-response-outcomes.aspx|2026: ATS International Conference]]))     * appear to have much better response to [[GLP-1analogs]] such as tirzepatide which can halve the OSA severity in this subtype compared with other patients with OSA(([[https://www.news-medical.net/news/20260519/Researchers-identity-patients-with-exceptional-tirzepatide-response-outcomes.aspx|2026: ATS International Conference]]))
-    * younger and had milder obesity, and they also had specific characteristics related to the underlying cause of their sleep apnea, including more severe upper-airway collapsibility, greater breathing control instability (called "high loop gain"), and a tendency to wake themselves up more easily with airflow obstruction+    * younger with milder obesity, and also had specific characteristics related to the underlying cause of their sleep apnea, including more severe upper-airway collapsibility, greater breathing control instability (called "high loop gain"), and a tendency to wake themselves up more easily with airflow obstruction
 =====Adverse effects of OSA===== =====Adverse effects of OSA=====
     * poor sleep causing daytime sleepiness and difficulty concentrating, poor attention span     * poor sleep causing daytime sleepiness and difficulty concentrating, poor attention span
osa.txt · Last modified: 2026/05/19 22:03 by wh

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