renal_clearance
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| renal_clearance [2026/08/10 10:09] – [renal clearance / excretion] gary1 | renal_clearance [2026/08/10 10:11] (current) – [Example - how long does it take to excrete a meal's worth or uric acid?] gary1 | ||
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| - | =====Example - how long does it take to excrete a meal's worth or uric acid?===== | + | =====Example - how long does it take to excrete a meal's worth of uric acid?===== |
| ***normal serum concentrations generally range from 3.4 to 7.2 mg/dL (0.20–0.43 mmol/L) in men** | ***normal serum concentrations generally range from 3.4 to 7.2 mg/dL (0.20–0.43 mmol/L) in men** | ||
| *uric acid poorly crosses cell membranes hence **volume of distribution (Vd) = 0.2-0.3L/ | *uric acid poorly crosses cell membranes hence **volume of distribution (Vd) = 0.2-0.3L/ | ||
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| *a 300g steak plus a beer gives ~450mg purines of which ~270mg is absorbed and metabolized which gives about 324mg uric acid | *a 300g steak plus a beer gives ~450mg purines of which ~270mg is absorbed and metabolized which gives about 324mg uric acid | ||
| *assuming 324mg uric acid is absorbed, the expected rise in serum levels would be = 324mg / 17L = 19mg/L = 1.9mg/ | *assuming 324mg uric acid is absorbed, the expected rise in serum levels would be = 324mg / 17L = 19mg/L = 1.9mg/ | ||
| - | *a renal clearance of 12mL/min for uric acid (upper limit normal range) with serum levels of 10mg/dL would give a uric acid excretion rate of 72mg/hr and thus **take the kidneys several hours to reduce serum uric acid levels back to normal after this spike** (even longer if impaired renal function, concomitant alcohol or a larger intake) | + | *a renal clearance of 12mL/min for uric acid (upper limit normal range) with serum levels of 10mg/dL would give a uric acid excretion rate of 72mg/hr and thus **take the kidneys several hours to reduce serum uric acid levels back to normal after this spike** (actually longer as does not take into account endogenous production rate and even longer if impaired renal function, concomitant alcohol or a larger intake) |
renal_clearance.txt · Last modified: 2026/08/10 10:11 by gary1