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| sleep [2026/05/28 14:16] – [sleep] gary1 | sleep [2026/07/27 22:57] (current) – [Introduction] gary1 |
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| * there appears to be a 90% reduction in glymphatic clearance during wakefulness, and twice the amount of protein clearance from the brain intima during sleep - and it appears that **the majority of glymphatic clearance activity occurs during N3 sleep which occurs in non-REM deep sleep** and glymphatic transport is most efficient in the right lateral sleeping position, with more CSF clearance occurring compared to supine and prone. (([[https://pmc.ncbi.nlm.nih.gov/articles/PMC7698404/|2020: The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices]])) | * there appears to be a 90% reduction in glymphatic clearance during wakefulness, and twice the amount of protein clearance from the brain intima during sleep - and it appears that **the majority of glymphatic clearance activity occurs during N3 sleep which occurs in non-REM deep sleep** and glymphatic transport is most efficient in the right lateral sleeping position, with more CSF clearance occurring compared to supine and prone. (([[https://pmc.ncbi.nlm.nih.gov/articles/PMC7698404/|2020: The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices]])) |
| *it has been proposed that glymphatic dysfunction is the central cause of [[n_delirium]](([[https://www.nature.com/articles/s41582-026-01194-y|2026: Glymphatic dysfunction: a unifying hypothesis for delirium]])) | *it has been proposed that glymphatic dysfunction is the central cause of [[n_delirium]](([[https://www.nature.com/articles/s41582-026-01194-y|2026: Glymphatic dysfunction: a unifying hypothesis for delirium]])) |
| | ***slow wave sleep is critical for consolidation of [[memory]]** |
