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--- sleep_physiology [2026/05/28 13:39] – [physiology of sleep] gary1
+++ sleep_physiology [2026/05/28 13:43] (current) – [non-REM N3 sleep appears to ve critical for CNS toxin removal via the glymphatic system] gary1
@@ Line 181: / Line 181: @@
-=====non-REM N3 sleep appears to ve critical for CNS toxin removal via the glymphatic system =====
+=====non-REM N3 sleep appears to be critical for CNS toxin removal via the glymphatic system =====
-  *discovered in 2012, the glymphatic system is a “pseudo-lymphatic” perivascular network distributed throughout the brain, responsible for replenishing as well as cleansing the brain.
+  ***see [[glymphatic_system]]**
-  *glymphatic clearance is the macroscopic process of convective fluid transport in which harmful interstitial metabolic waste products are removed from the brain intima
-  *sleep is a primary driver of glymphatic clearance - there appears to be a 90% reduction in glymphatic clearance during wakefulness, and twice the amount of protein clearance from the brain intima during sleep - and it appears that **the majority of glymphatic clearance activity occurs during N3 sleep which occurs in non-REM deep sleep** and glymphatic transport is most efficient in the right lateral sleeping position, with more CSF clearance occurring compared to supine and prone. (([[https://pmc.ncbi.nlm.nih.gov/articles/PMC7698404/|2020: The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices]]))
-  *it appears to reduce in efficiency as we age
-  *low doses of alcohol (0.5 g/kg) appears to increase glymphatic clearance b ut higher levels reduce it
-  *glymphatic clearance can be manipulated by sleep deprivation, cisterna magna puncture, acetazolamide or genetic deletion of AQP4 channels
 =====Poor sleep is associated with health issues=====