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toxoplasmosis [2026/01/07 22:56] – [Introduction] gary1toxoplasmosis [2026/08/12 10:13] (current) – [Life cycle] gary1
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   *unlike other forms of the parasites, the oocytes can survive for long periods in water   *unlike other forms of the parasites, the oocytes can survive for long periods in water
   *the oocytes are ingested by other mammalian hosts (including marine) which then excyst and invade the host as tachyzoites which may become tissue cysts in the form of bradyzoites which are very resistant to antimicrobial medications   *the oocytes are ingested by other mammalian hosts (including marine) which then excyst and invade the host as tachyzoites which may become tissue cysts in the form of bradyzoites which are very resistant to antimicrobial medications
 +    * the protein TgPRO produced by Toxoplasma, allows Toxoplasma packed into a tissue cysts to manage oxidative stress that can damage cells by controlling genes involved in energy production and iron use - it appears TgPRO supports parasite growth in the naturally dense environment of a chronic-stage cyst(([[https://www.cell.com/cell/fulltext/S0092-8674(26)00827-5|2026: Convergent evolution of metabolic regulation governs redox adaptation in Toxoplasma]]))
   *oocytes also excyst in tissues after parenteral innoculation   *oocytes also excyst in tissues after parenteral innoculation
   *tachyzoites and bradyzoites are killed by water   *tachyzoites and bradyzoites are killed by water
toxoplasmosis.txt · Last modified: 2026/08/12 10:13 by gary1

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