brexpiprazole (Rexulti)

see also:

• anti-psychotic medications

• an atypical anti-psychotic medication
• listed on Aust. PBS in late 2017 for Rx of schizophrenia, with the advantage of less weight gain or diabetic effects

• hypersensitivity to brexpiprazole
• dementia
• liver disease
• renal disease
• dementia
• diabetes mellitus or risk of it
• hyperlipidaemia
• cardiac disease
• seizures
• stroke
• dysphagia
• neutropenia
• obstructive sleep apnoea
• age < 18yrs not approved
• pregnancy - use in 3rd TM may cause problems with the newborn
• lactation - unknown safety
• deep venous thrombosis (DVT) risk factors

• drowsiness - avoid driving or use of machinery, or other sedatives including alcohol
• hypotension
• increase suicidality in young people
• decrease perspiration and increase risk of heat illness in hot weather
• increase appetite and weight gain, although this may be less than some other anti-psychotics
• restlessness
• hyperglycamia
• hyperprolactinaemia
• increased risk of deep venous thrombosis (DVT)?
• rarely:
  • neuroleptic malignant syndrome (NMS)
  • tardive dyskinesia which may be permanent
  • anaphylaxis