flucloxacillin

see also:

• penicillins
• antibiotics for Rx of Staph. aureus

• flucloxacillin is a narrow spectrum penicillin active against Gram +ves including St. aureus
• not active against Gram negative bacilli, methicillin resistant Staphylococcus, nor Streptococcus faecalis.
• category B1 in pregnancy
• is excreted in breast milk in trace amounts. An alternative feeding method is recommended to avoid any possible sensitisation of the newborn.

• HS to penicillins or cephalosporins
• PH flucloxacillin associated jaundice or hepatic dysfunction

• HS reaction including anaphylaxis
• Antibiotic associated pseudomembranous colitis
• cholestatic jaundice - usually after several weeks of Rx
• reduces binding of bilirubin to albumin thus avoid in jaundiced neonates or premature neonates
• sodium load in renally impaired patients - each 1g flucloxacillin contains 2mmol sodium

• adults 500mg qid
• children 2-10 years 250mg qid
• children < 2yrs: 125mg qid

• adult dose 500mg - 1g 6hrly
• children 2-10 years 250-500mg qid
• children < 2yrs: 125-250mg qid