sleep

see also:

• sleep hygiene
• physiology of sleep
• insomnia
• snoring
• obstructive sleep apnoea (OSA)
• fatigue
• stress
• Coping with shift work
• managing jet lag and your body clock

• sleep is a primary driver of glymphatic clearance removing wastes from the brain
  • there appears to be a 90% reduction in glymphatic clearance during wakefulness, and twice the amount of protein clearance from the brain intima during sleep - and it appears that the majority of glymphatic clearance activity occurs during N3 sleep which occurs in non-REM deep sleep and glymphatic transport is most efficient in the right lateral sleeping position, with more CSF clearance occurring compared to supine and prone. ¹⁾
  • it has been proposed that glymphatic dysfunction is the central cause of delirium²⁾