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  • a dihydropyridine calcium blocking agent
  • act mainly on arteriolar smooth muscle to reduce peripheral vascular resistance and thus reduces blood pressure
  • often formulated with other agents such as statins, ACE inhibitors




  • liver impairment
  • grapefruit juice as this is an inhibitor of the CYP-3A4 enzyme and may cause toxicity of verapamil and other calcium channel blockers
  • lactation

adverse effects

  • hypotension
  • peripheral oedema which is NOT responsive to diuretics which will only cause volume depletion
  • constipation
  • negative inotropic effect and cardiac failure risk as well as cardiac conduction blockade - although less risk than with verapamil (Isoptin)
  • rarely, myasthenia-like neuromuscular disease


acute ED Rx of hypertension

  • 5-10mg orally stat

chronic Rx of hypertension, angina or Raynaud's phenomenon

  • 2.5-10mg orally once daily
amlodipine.txt · Last modified: 2015/12/31 04:29 by

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