antineutrophil cytoplasmic antibodies (ANCAs)
- these antibodies characteristically occur in vasculitic syndromes
- occur in more than 90% of patients with systemic Wegener's granulomatosis (with renal or pulmonary involvement, or both), 75% of patients with limited Wegener's granulomatosis (without renal involvement) and 50% of patients with microscopic polyarteritis.
- c-ANCAs are actually antibodies to protein 3. The presence of c-ANCAs is 98% specific for these diseases;
- changes in c-ANCA levels often precede disease activity and may guide treatment.
- a primary care physician will rarely need to order this test
- it helps in the diagnosis and management of only a very small number of patients with relatively rare conditions, and screening patients with nonspecific symptoms results in many false-positive p-ANCA results
anca.txt · Last modified: 2015/12/29 04:31 by 127.0.0.1