- Unusually potent at antag. effects of pentylenetetrazol but almost without action in ECT-induced seizures thus has anticonvulsant activity in wide range of seizure type with notable exception of generalised tonic-clonic seizures & thus useful in absences & myoclonic seizures in children but tolerance to these actions often develop after 1-6mths when no dose of clonazepam will be of use!!;
- Plasma Rx range not helpful; Optimal dose hard to predict;
- To avoid sedation/irritability, keep initial dose low (eg. 0.25mg bd) & increased wkly.
- Chronic use → behav. effects, drowsiness, lethargy, hypotonia;
- After IV dose → redistributed (→ muscle → fat) terminating action;
Clinical usage and dosages
- useful in acute Mx of absences & myoclonic seizures in children
- Draw up all of 1ml ampoule (ie. 1mg) of clonazepam into 2ml syringe and dilute with 1ml diluent thus making final concentration of 0.5mg/ml.
- ventilated neonate: 0.25mg IV
- Give 0.25mg slow IV over 1min, and repeat in 0.125mg doses every 2-3min as needed up to 1mg over 5-10min.
- adult 1.0mg IV
clonazepam.txt · Last modified: 2011/08/25 11:22 by 127.0.0.1