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gastrointestinal stromal tumors (GIST)

see also:


  • a rare type of GIT tumour (some are benign, some are malignant) believed to originate in cells found between muscle layers of the gastro-intestinal tract, called Interstitial cells of Cajal (ICC) and generally grow outwards
  • 50-60% arise in the stomach
  • 30-40% arise in small intestines


  • increasing age
  • genetic risk factors
    • Neurofibromatosis type 1
    • Carney Triad
      • a rare syndrome defined by the coexistence of three specific tumours and typically affecting young people

Clinical features

  • usually asymptomatic
  • may cause pain, bloating, fatigue, occult or overt GIT bleeding


  • may be picked up on gastroscopy or CT scan
  • biopsy to confirm benign vs malignant status


  • most are treated with surgical excision
  • imatinib is used to treat GIST that cannot be removed by surgery
gist.txt · Last modified: 2021/07/29 13:51 by gary1