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myeloproliferative_disorders

myeloproliferative disorders

introduction

  • myeloproliferative disorders are a heterogenous group of at least 4 chronic disorders characterized by cellular proliferation of 1 or more hematologic cell lines in the peripheral blood, distinct from acute leukaemia
  • these include:
  • these are usually associated with acquired (rarely inherited) mutations of genes including:
  • patients are at risk for:
    • thrombotic events such as stroke (CVA)
    • haemorrhagic events
    • infection
    • reactivation of herpes zoster
    • anorexia, weight loss
    • priapism, tinnitus, or stupor from leukostasis
    • developing secondary acute leukemia from their underlying disorder, as well as from their treatment (radioactive phosphorus but not hydroxyurea increased risk of myelodysplastic syndrome and AML)
    • development of myelofibrosis secondary to Rx by hydroxyurea of other myeloproliferative disorders
myeloproliferative_disorders.txt · Last modified: 2014/11/24 10:00 by 127.0.0.1

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