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n_mnd [2020/06/14 00:02]
gary1 [Amyotrophic lateral sclerosis (ALS)]
n_mnd [2021/02/24 21:17]
gary1 [Amyotrophic lateral sclerosis (ALS)]
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 =====Amyotrophic lateral sclerosis (ALS)===== =====Amyotrophic lateral sclerosis (ALS)=====
   *aka Lou Gehrig's disease   *aka Lou Gehrig's disease
-  * progressive degeneration of motor nerve cells in the brain (upper motor neurons) and spinal cord (lower motor neurons)+  * progressive degeneration of motor nerve cells in the brain (upper motor neurons) and spinal cord (lower motor neurons) associated with impaired folding of neuronal intracellular proteins resulting in mSOD1 toxicity and TDP‐43 pathology 
 +  * in 2021 it was reported than a new compound NU-9 was able to reduce this protein abnormal folding, improve mitochondrial and endoplasmic reticulum function and reverse the neuronal degeneration over 90 days in mice(([[https://doi.org/10.1002/ctm2.336|Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology]]))
   * most develop it between 40-70yrs, especially 60-70yrs but can occur younger   * most develop it between 40-70yrs, especially 60-70yrs but can occur younger
   * similar incidence as [[MS]] and accounts for 5 of every 100,000 adult deaths   * similar incidence as [[MS]] and accounts for 5 of every 100,000 adult deaths
n_mnd.txt · Last modified: 2021/02/24 21:25 by gary1